Chronic active Epstein-Barr virus infection and related diseases

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[Chronic active Epstein-Barr virus infection].

The ubiquitous Epstein-Barr virus (EBV), which establishes latency after primary infection, does not cause any symptomatic diseases as long as cellular immunity is intact. In apparently immunocompetent individuals, a chronic infection can develop, and this has been called as chronic active EBV infection (CAEBV). CAEBV is characterized by chronic or recurrent infectious mononucleosis-like sympto...

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Features of Chronic Active Epstein-Barr virus Infection and Related Human Diseases

A chronic undefined illness characterized by infectious mononucleosis (IM)-like symptoms and signs, possibly associated with Epstein-Barr virus (EBV) infection, designated as so-called chronic active EBV infection (CAEBV), is focused and discussed in this mini-review. Patients with CAEBV often develop T cell lymphoproliferative disorder (LPD)/lymphoma or NK cell LPD/lymphoma. Unique manifestati...

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Elevated IgA antibodies to Epstein-Barr virus in children with chronic active Epstein-Barr virus infection.

Anti-Epstein-Barr virus (EBV) antibodies were tested in 11 children with chronic active EBV infection. Anti-virus capsid antigen (VCA)-IgG antibody titers ranged from 1:640 to 1:10,240. Anti-VCA-IgM antibody was consistently positive in 5 of the 11 patients; anti-VCA-IgA antibody was consistently positive in 6 of the 10 patients; anti-early antigen (EA)-IgG antibody was consistently positive in...

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Epstein-Barr virus infection and gastrointestinal diseases

Epstein-Barr is a member of the herpesvirus family that infects more than 90% of the world‘s population. Although primary infection typically occurs within the first few years of life or in adolescence and is generally asymptomatic or results in infectious mononucleosis respectively, in some cases the virus is implicated with the development of a large spectrum of gastrointestinal malignant and...

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Prognostic factors for chronic active Epstein-Barr virus infection.

Chronic active Epstein-Barr virus infection (CAEBV) is a high-mortality and high-morbidity disease. To clarify the prognostic factors, a national survey was performed in Japan, and data for 82 patients who met the criteria for CAEBV were analyzed. Of these 82 patients, 47 were alive and 35 had already died. Multivariate analysis revealed that thromobocytopenia and age at disease onset were corr...

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ژورنال

عنوان ژورنال: Japanese Journal of Clinical Immunology

سال: 2003

ISSN: 0911-4300,1349-7413

DOI: 10.2177/jsci.26.283